Transcriptional Regulation of the Carcinoembryonic Antigen Gene

Carcinoembryonic Antigen Gene Family

The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin supergene family and can be divided into two main subgroups based on sequence comparisons. In humans it is clustered on the long arm of chromosome 19 and consists of approximately 20 genes. The CEA subgroup genes code for CEA and its classical crossreacting antigens, which are mainly membrane-bound, whereas the other s...

The 3' untranslated region of the carcinoembryonic antigen gene plays a minimal role in the regulation of gene expression.

Carcinoembryonic antigen (CEA), an oncofetal glycoprotein, is overexpressed in both colonic tumor tissue and in aberrant crypt foci. The 3' untranslated region (UTR) of CEA, which has been postulated to play a role in CEA expression, contains an oligo-A region. Sequence instability at oligo-A regions occurs in colorectal cancer, and it has been suggested that these mutations may alter expressio...

Baculovirus recombinants expressing the human carcinoembryonic antigen gene.

Carcinoembryonic antigen (CEA), one of the most extensively studied human tumor-associated antigens, represents a potential target for passive as well as active immunotherapy. We describe here the first baculovirus recombinants expressing the human CEA gene. Eight baculovirus clones were isolated which expressed products of varying molecular weights; one clone, termed BVCEA-140, was shown to co...

The transcriptional regulation of the preproenkephalin gene.

Serum Levels of Carcinoembryonic Antigen and a Tumor-extracted Carcinoembryonic Antigen-related Antigen in Cancer Patients1

Levels of Carcinoembryonic antigen (CEA) and a tumor-ex tracted CEA-related antigen (TEX) were determined in sera from patients with carcinomas of the breast, colon, lung, head and neck, and a number of miscellaneous categories. The purpose of this study was to compare the levels of each antigen at various stages of malignant disease. Competitive radioimmunoassays developed in our laboratory we...